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His son Brodie, seeing little opportunity in a small rural tobacco factory, moved to Durham in 1869

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The omission of e-cigarettes in the majority of subnational smoke-free laws may lead to confusion and poor adherence to existing smoke-free regulations 25 , impeding efforts to achieve a 100% smoke-free environment

The most effective approach combines a behavioral replacement (fake cigarette, nicotine-free vape, or pouch) with NRT or prescription medication like varenicline